Friday, March 23, 2012

Steroids and their affects

The role of steroid actions on hormones has reported to have an affect on children (re: what roids have wrought)  - the specifics I know not, but it makes sense that particular 'guys' thrown into the blood stream will work their way into cells, manipulate the said machinery's, and their new introduction will cause the silent proteins within to alter the architecture of DNA reading mechanisms so some are turned on, others off (and this no doubt will carry some info in the sperm, as the organism is altering his DNA by doing this).

I always find myself immediately looking at the children of someone whose used 'steroids', seeing if I can glance any sort of abnormal hormone development (very arm chair genetic like and prejudicial).

On a side note: the mechanisms of steroids and their friends has been a bit of a curious phenomena because humans care for it (the majority) only for its aesthetic effects on muscle and its visual associated pleasantries - whatever 'gets off' the protein creating pathways, that'll work! Thus companies have been taking mimics ('stereoisomers') of the said sex hormone, hoping a similar shapped molecule (ball) will somewhat land on a similar shaped receptor (hole) and the said effect (stimulation of the pathways) will be somewhat similar.

The process by itself of 'lifting' is very curious - it was only by chance that some ancestor of ours had these musculature cells increase in properties (and eventually size) in response to use (much like brain cells adapt according to stimulate - memory, etc).  How crazy is it that the placement of something from here to there causes some physical thing within an arm to alter, DNA is actually messed with, and that bulge becomes larger! To relate the stereoisomer idea and the epigenetics of steroids to this, the body is holistic, there is the endocrine, sympathetic and autosympathetic nervous systems, digestive, reproductive, etc - each one monitors the other, and each one adapts to the other (or the system to itself). Thus, introduction of artificial hormones leads the bodys 'hormone level sense machine' to less its own internal production in response, but thats just the body limiting the production of one shape of molecule. Increase visualization, increase power of nerve impulse power -> increase sympatic strength and number of transmitters dumped on muscle fibers (no hormones needed) - alter proprioceptive properties (pain centers), now all of a sudden the organism will not stop a particular level of stimulation, and the muscle will go to lengths its never gone before. The insulin response also facilitate muscle growth (digestive interacting with muscular system) - how it works I'm not certain, but many a supplement company will argue some effect exists, and their product will use this idea, albeit always only 100% to your advantage!

Thursday, April 21, 2011

"An Implacable, shape shifting foe"

Title :"An Implacable, shape shifting foe"

Quote: What first was seed, becomes grass, then an ear, then bread, chyle,
blood, semen, embryo, man, a corpse: then again earth, stone, or some other
mass, and so forth.Here we perceive something which changes in all these things,
and ever remains the same.. Matter, considered absolutely, comprises all forms
and dimensions. But the variety of forms which it assumes is not received from
without, but is produced and engendered from within. - Giordano Bruno 1500s

What did one man call 'the emperor of all maladies, the king of our terrors'? Another the 'most relentless and insidious enemy' - the 'quintessential disease of pathological hyperplasia?' Still further: 'An implacable, shape shifting foe... the greatest scourge that has ever assailed the human race!'
What was the thing that finally extinguished 'the fire of life' from Napolean - that ended the existence of that King of kings, who could conquer Nations and create Empires, yet could not, in the end, conquer this?
In 50 BC a Persian queen, ravaged, heartbroken, and destitute, grabbed her favorite slave, handed him a knife and said 'begin cutting'. She exposed her breast, and the slave commenced.
The queen had the slave ‘extricate’ (literally cut) a cancerous tumor, a bump on the woman's chest, from her bosom, and today, some 2,000 years later, this method - 'the cold knife' is still the most affective cancer treatment. (The other, often done after the cutting, just to prevent any chance that some rogue cancer cell escaped to other distant parts of the body, is to shoot radioactive particles at the person in a cold chamber. They lose their hair, but during the process they get to listen to music.)
'Cells possessed with an autonomous will to divide' . This is how one definitive medicinal dictionary terms it. Another describes it as “cells refusing to commit cell suicide”. In order to understand the illness one must first one confront a mystifying truism – you and I, what we think of as a whole, complete selves, are really the assimilation of 9 trillion entities. They’re cells, which once started just as one long ago in the womb of our mothers. Ever since the ‘chosen first one’, “we’ve” been replicating geometrically ever since. Another worthy mention is that shortly before we begot arms and legs, toes and forefinger – we had gills. (Though just for a little while). Also prominent, a tail stub (hence ‘the tailbone’) – but programmed destruction of this rudimentary feature happened shortly thereafter, and now our bodies adorn appearances more suitable. These two things are examples of how, without destroying, and alternatively ‘begotting’ new cells, there would be no development, no healing, no mystifying property of ‘life’ – this is why life isn’t inert. The veil shown to us from Cancer is that without ‘all cells agreeing’ to work as a whole in the environment we call the body[cells agreeing to kill themselves at designated times without shooting out their innards], the whole ‘body ecosystem’ will collapse, one part necessary to ‘give life’ to another will falter, and from there the jenga blocks fall.

The disease, or pest, you can think of it, is one rogue out of the trillion, (through whatever the initial mechanism) refusing to sacrifice himself for the others. 'Why ought I', says the cell, 'lay down and split, make a copy and end my life'? 'Who are you, dear ones, to require me to kill myself?' 'I will learn to get my own food, I will create my own blood vessels (angiogenesis), move to my own territories (metastasis), do all I need to do, as Emerson said, to 'never imitate. Live in my own fashion' .
The fun begins when you consider the implications. The distant past shows themes of cooperation:

Genes joined to form genomes, prokaryotic cells incorporated protobacteria as
mitochondria to become eukaryotic cells, single-celled organisms joined together
to become multicellular organisms, multicellular organisms became eusocial
societies, and multicellular species joined with either unicellular species or
other multicellular species to become interspecific mutualisms 1
This means, in our distance past, one ‘original’ might’ve been immortal – never dividing, always living – a fountain of youth by natural disposition! Who are we to tell them to die, to 'lay down their lives' for some distant offspring! Could it not be, that through some 'unfortunate mutation' , some would 'split', giving the 'elder forebearer' death, and the young one life! who would've thought - death, our notion of life and its counterpart, are really just the forced consequences of the extinguishment of the 'immortal propensity'. Death evolved, aging evolved. One mutation to a common pathway can double the lifespan of a species, and it all relates to the mechanisms of cell death, and why things die in the first place. Scary to think that the unveiling of a mystery which has plagued hundreds of millions up until now, in our current age and epoch, might reveal clues to those seeking an answer to another - the end of aging.

Tuesday, April 12, 2011

But Nature Demands the Flame

" I mourned for Paul and I also mourned for myself and for the loss of the word drenched companionship we created, due to a tiny land mine traveling through his blood vesssels. Beneath our civilized hair and hide, and beneath awareness even, we easily destroy ourselves. To be so Godlike, and yet so Fragile. "

This beautifully describes the reality of a stroke, how, 20 years of 'further education' and time collecting, gathering, and exhuming tte works of others [he was an English Professor, graduated 1st at Oxford, wrote 50 books] and consuming their phrases can be utterly stolen fom you forever due to a tiny rock - lodged in a vessel - for 10 seconds. Bang - all over, done, gone. The loss of blood causes nerve cells to commit suicide, and those peices of material matter were the things which we ephemerally associate with consciousness, memory, creativity, ability to use speech!

"The deified Augustus, to whom the gods vouchsafed more than any other man, did not cease to pray for rest and to seek release from public affairs; all his conversation ever reverted to this subject in his hope of leisure... He who saw everything depending upon himself alone, who determines the fortunes of individuals and nations, thought most happily of that future day on which he should lay aside his greatness. .. And so he longed for leisure, in the hope and thought of which he found relief for his labours. This was the prayer of one who was able to answer the prayers of mankind. "
Let the words spoken before go forever speaking - heed the above, so no longer are we 'unawares' of this prior wisdom!

Other fun:
"A computer with a large sleek monitor.. [while] ripped out newspaper and magazine clippings filled a series of wooden filing cabinets and [there were] overflowing three-ring binders I affectionately loved.. "my portable universe", a repository of things I found curious.

"Quietly, sometimes, unawares"

"Life lives in nuances and innuendos. How could Paul's immense cosmos of words shrink to the size of a communication board overnight?"

"No more confiding, whispering intimacies, playing with words, sharing the world?"

"Paul patrolled the darker recesses of the night."

"I crossed the threshold into a world that was unfamiliar, with an unfamiliar man lying in it."

"[Raccoon Young] are born blind, deaf, and furry"

"Your poor battered brain, I thought, trying to peer through bone on the left side of his head, to where the brain stores the memories of how things are done, how to perform a simple task. His stroke somewhere in that region had clearly unskilled him. Now his years had come unglued."

Wednesday, March 2, 2011

The world of DNA - what 9 out of 10 peices of it does

Take your DNA, cut it into bits, 9 out of 10 of them 'does nothing' - they don't make proteins - they aren't 'genes' in any sense - 'they are junk'. Or so people say - no, no it isn't, at least this was discovered onyl 20 years ago, some create RNAs, which won't make protein, but will go find peices of virus RNA and stick there, or block their machinery from being transcribed. They can also go float to other RNA's, and inactivate them, or block them as well. They are the 'interferers' - called in bio vernacular 'RNA interferers' or "RNAi's" - they are the new 'xfiles' of genetics - a new field that looks at DNA that isn't genes. Curious.

God did I miss this blog

God do I need this - the world of nature, when read through peer review articles and cloaked in the language of dog shit is horrible horrible horrible. It's almost like studying the field of art, but only in your spare time, when leisure permits, can you actually see a picasso, a "gogain", a da vinci, the rest of the time you must read art manuals and never know what it means to 'feel' the mysterious, to 'see beauty', to taste, touch, and feel excitement - what you get is the feeling someone is writing something because they are getting paid - worthy of hellfire motives - 'we all know this, so why complain, hasn't it always been thus and thus ever remain?'

Wednesday, February 2, 2011

Electrical the embryo

Beautiful words are like drugs, you can take them on any occasion, and make the dull and monotonous seem blissful, the lame ecstatic, the docile exuberant, the boring bewitched with eternal excitement. Wear beautiful words on these occasions and what once was something dull is now eternal pleasure. Not for nothing did poets lay themselves up in their rooms, to themselves only with words - Dreyden
This is something I found in a newspaper article about on a book on fame, which draws from quips made by the ancients like Cicero, Chaucer, etc, and compares their meanings to the current celebrity ilk - anyway, the book is curious, but a poem written in a review can very well be rearranged, so as instead of speaking about that transitory thingy - 'fame' - it discusses the individual life compared to 'the immortal protoplasm' 1

"Individual life is one that does not stay,
Its occupants must die
or out of sight of estimate
Ascend Incessantly,
or be that most insolvent thing,
A lightening in the germ
- Electrical the embryo
But Nature demands the flame."

1- 'Protoplasm' was the term this Cajal guy used in 1900 to describe the 4 billion year old replication machinery - since what little was avaliable to unveil the secret of the nucleus wasn't quite prepared. Note, also, before knowledge of the intricate workings of the cell, most people thought it was 'just protoplasm' and just 'bags of salt'. See Cajals' words.
Whither is life going? This protoplasm.. crawled in the caterpillar, dressed itself with rainbow colors in the plant, adorned itself with the crown of intelligence in the mammal. It began unconscious and ended conscious. It was the slave and plaything of the cosmic forces and it ended as the driver of nature and the autocratic of creation….Has life arched its limit and exhausted its fecundity in the human organism.. who knows? Perhaps this demigod, protoplasm, will also die.. Day of horror, solitude filled with anguish, night of utter darkness…
But no! This is impossible! When our miserable planet is worn out and frigid old age has consumed the fire at its heart, and the earth becomes a glacial and unproductive desert, and the red and dying sun threatens to overwhelm us with everlasting darkness - organism protoplasm will have attained the culmination of its work.. Then the king of Creation will abandon forever the humble cradle which rocked his infacy, will bodily attack other worlds, and will solemnly take possession of the universe!

Undergrades peirce the heart of the hidden - 'Good sires' lol

" Good performance is improved this way but occasionally good sires carrie freek charcters hidden. "

I just came across this and had to write about it - It appears to be some students account for all of the knowledge of hereditary up until 1955, and the language, though simple and error prone, is probably the deepest you'll ever get. It's from a 1955 copy of the journal Heredity.